منابع مشابه
Incarcerated Inguinal Hernia Mesh Repair: Effect on Testicular Blood Flow and Sperm Autoimmunity
BACKGROUND The aim of our study was to determine an influence of incarcerated inguinal hernia mesh repair on testicular circulation and to investigate consequent sperm autoimmunity as a possible reason for infertility. MATERIAL AND METHODS This prospective study was performed over a 3-year period, and 50 male patients were included; 25 of these patients underwent elective open mesh hernia repai...
متن کامل[Autoimmunity].
Autoimmune diseases comprise a large, diverse group of diseases characterized by a humoral or cell-mediated immune response against the constituents of the body's own tissues. In cases in which the host is sensitized with a tissue-specific antigen, a single pathological immune reaction occurs in the target organ. In those cases in which the host is sensitized with either a single tissue nonspec...
متن کاملCTLA4 Gene Variants in Autoimmunity and Cancer: a Comparative Review
Gene association studies are less appealing in cancer compared to autoimmune diseases. Complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, such as Grave’s disease, on which a large body of multicentre data is accumulated. For years t...
متن کاملActivating autoimmunity
A dangerously mutagenic protein is targeted to a single genomic site by ssDNA, report Ronai et al. (page 181). High frequency mutation at the immunoglobulin V region improves antibody affinity and specificity as part of the adaptive immune response. AID (activation-induced cytidine deaminase), which converts deoxycytidines to deoxyuridines, initiates this mutation process. These conversions the...
متن کاملSperm design and sperm function.
Spermatozoa vary enormously in their form and dimensions, both between and within species, yet how this variation translates into fertilizing efficiency is not known. Sperm swimming velocity is a key determinant of male fertilization success, but previous efforts to identity which sperm phenotypic traits are associated with swimming velocity have been unsuccessful. Here, we examine the relation...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2004
ISSN: 1460-2350
DOI: 10.1093/humrep/deh170